Jungmok Seo
High-throughput approaches for screening and analysis of cell behaviors
Seo, Jungmok; Shin, Jung Youn; Leijten, Jeroen; Jeon, Oju; Camci-Unal, Gulden; Dikina, Anna D.; Brinegar, Katelyn; Ghaemmaghami, Amir M.; Alsberg, Eben; Khademhosseini, Ali
Authors
Jung Youn Shin
Jeroen Leijten
Oju Jeon
Gulden Camci-Unal
Anna D. Dikina
Katelyn Brinegar
Professor AMIR GHAEMMAGHAMI AMIR.GHAEMMAGHAMI@NOTTINGHAM.AC.UK
Professor of Immunology and Immuno- Bioengineering
Eben Alsberg
Ali Khademhosseini
Abstract
The rapid development of new biomaterials and techniques to modify them challenge our capability to characterize them using conventional methods. In response, numerous high-throughput (HT) strategies are being developed to analyze biomaterials and their interactions with cells using combinatorial approaches. Moreover, these systematic analyses have the power to uncover effects of delivered soluble bioactive molecules on cell responses. In this review, we describe the recent developments in HT approaches that help identify cellular microenvironments affecting cell behaviors and highlight HT screening of biochemical libraries for gene delivery, drug discovery, and toxicological studies. We also discuss HT techniques for the analyses of cell secreted biomolecules and provide perspectives on the future utility of HT approaches in biomedical engineering.
Citation
Seo, J., Shin, J. Y., Leijten, J., Jeon, O., Camci-Unal, G., Dikina, A. D., …Khademhosseini, A. (2018). High-throughput approaches for screening and analysis of cell behaviors. Biomaterials, 153, 85-101. https://doi.org/10.1016/j.biomaterials.2017.06.022
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 19, 2017 |
Online Publication Date | Nov 14, 2017 |
Publication Date | Jan 1, 2018 |
Deposit Date | Aug 19, 2022 |
Journal | Biomaterials |
Print ISSN | 0142-9612 |
Electronic ISSN | 1878-5905 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 153 |
Pages | 85-101 |
DOI | https://doi.org/10.1016/j.biomaterials.2017.06.022 |
Public URL | https://nottingham-repository.worktribe.com/output/3097094 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0142961217304209?via%3Dihub |
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