Ching Lam
Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging
Lam, Ching; Sanders, David; Lanyon, Peter; Garsed, Klara; Foley, Stephen; Pritchard, Susan; Marciani, Luca; Hoad, Caroline L.; Costigan, Carolyn; Gowland, Penny; Spiller, Robin
Authors
David Sanders
Peter Lanyon
Klara Garsed
Stephen Foley
Susan Pritchard
LUCA MARCIANI LUCA.MARCIANI@NOTTINGHAM.AC.UK
Professor of Gastrointestinal Imaging
CAROLINE HOAD CAROLINE.L.HOAD@NOTTINGHAM.AC.UK
Senior Research Fellow
Carolyn Costigan
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
ROBIN SPILLER ROBIN.SPILLER@NOTTINGHAM.AC.UK
Professor of Gastroenterology
Abstract
Background and aims: The regular overnight migrating motor complex (MMC) ensures that the normal fasting small bowel water content (SBWC) is minimised. We have applied our recently validated non-invasive magnetic resonance technique to assess SBWC in newly diagnosed coeliac disease (CD), scleroderma (SCD) and irritable bowel syndrome (IBS) conditions, possibly associated with small intestinal bacterial overgrowth (SIBO).
Methods: 20 CD and 15 SCD patients with gastrointestinal symptoms were compared to 20 healthy volunteers (HV) and 26 IBS with diarrhoea (IBS-D) patients as previously reported. All underwent a fasting, magnetic resonance imaging (MRI) scan on a 1.5 T Philips Achieva MRI scanner to assess fasting SBWC and colonic volumes. Stool and symptom diaries were completed for 1 week.
Results: Median (Interquartile range, IQR)
Compared to healthy volunteers, all the patients had significantly increased stool frequency and Bristol stool form score. SBWC was significantly increased in CD 109(53-224) vs. 53(31-98) mL in HV, p [less than] 0.01 and 42 (28-67) in IBS-D, p [less than] 0.01. Variable increase in SBWC was also found in SCD, median 77(39-158) but this was not significant, p=0.2. Colonic volumes were similar for all groups being 547 (442-786) for CD, 511 (453-789) for SCD, 612 (445-746) for HV and 521 (428-757) mL for IBS-D. When CD patients were subdivided according to the Marsh classification, the higher grades had larger colonic volumes.
Conclusion: Fasting SBWC as assessed by MRI is significantly increased in newly diagnosed CD and SCD but decreased in IBS-D. Future studies should test whether increased resting fluid predisposes to SIBO.
Citation
Lam, C., Sanders, D., Lanyon, P., Garsed, K., Foley, S., Pritchard, S., …Spiller, R. (2019). Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging. United European Gastroenterology Journal, 7(10), 1353-1360. https://doi.org/10.1177/2050640619860372
Journal Article Type | Article |
---|---|
Acceptance Date | May 28, 2019 |
Online Publication Date | Jun 21, 2019 |
Publication Date | Dec 1, 2019 |
Deposit Date | Jun 14, 2019 |
Publicly Available Date | Mar 29, 2024 |
Journal | United European Gastroenterology Journal |
Print ISSN | 2050-6406 |
Electronic ISSN | 2050-6414 |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
Volume | 7 |
Issue | 10 |
Pages | 1353-1360 |
DOI | https://doi.org/10.1177/2050640619860372 |
Keywords | Small bowel; Magnetic resonance imaging; Irritable bowel syndrome; Coeliac disease; Scleroderma |
Public URL | https://nottingham-repository.worktribe.com/output/2188020 |
Publisher URL | https://journals.sagepub.com/doi/full/10.1177/2050640619860372 |
Additional Information | Lam, C., Sanders, D. S., Lanyon, P., Garsed, K., Foley, S., Pritchard, S., … Spiller, R. (2019). Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging. United European Gastroenterology Journal. https://doi.org/10.1177/2050640619860372 |
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