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Outputs (9)

Management and outcomes for older women with early breast cancer treated with primary endocrine therapy (PET) (2024)
Journal Article
Hubbard, T., Wright, G., Morgan, J., Martin, C., Walters, S., Cheung, K.-L., Audisio, R., Reed, M., & Wyld, L. (2024). Management and outcomes for older women with early breast cancer treated with primary endocrine therapy (PET). Breast, 77, Article 103768. https://doi.org/10.1016/j.breast.2024.103768

Background: This study reports the detailed management and outcomes of women treated with Primary Endocrine Therapy (PET) in a large prospective UK cohort of older women (≥70) with breast cancer. Methods: This was an unplanned secondary analysis of a... Read More about Management and outcomes for older women with early breast cancer treated with primary endocrine therapy (PET).

Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives (2024)
Journal Article
Mizutani, T., Cheung, K.-L., Hakobyan, Y., Lane, H., Decoster, L., Karnakis, T., Puts, M., Calderon, O., Jørgensen, T. L., Boulahssass, R., Wedding, U., Karampeazis, A., Chan, W. W. L., Banerjee, J., Falci, C., van Leeuwen, B. L., Fonseca, V., Gironés Sarrió, R., Vetter, M., Dougoud, V., …Kanesvaran, R. (2024). Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives. Journal of Geriatric Oncology, 15(2), Article 10179. https://doi.org/10.1016/j.jgo.2024.101709

Introduction
The Sustainable Development Goals of the United Nations include a commitment to “leave no one behind” as a universal goal. To achieve this in geriatric oncology (GO) worldwide, it is important to understand the current state of GO at an... Read More about Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives.

Survival Outcomes in Older Women with Oestrogen-Receptor-Positive Early-Stage Breast Cancer: Primary Endocrine Therapy vs. Surgery by Comorbidity and Frailty Levels (2024)
Journal Article
Wang, Y., Steinke, D., Gavan, S. P., Chen, T.-C., Carr, M. J., Ashcroft, D. M., …Chen, L.-C. (2024). Survival Outcomes in Older Women with Oestrogen-Receptor-Positive Early-Stage Breast Cancer: Primary Endocrine Therapy vs. Surgery by Comorbidity and Frailty Levels. Cancers, 16(4), Article 749. https://doi.org/10.3390/cancers16040749

Primary endocrine therapy (PET) offers non-surgical treatment for older women with early-stage breast cancer who are unsuitable for surgery due to frailty or comorbidity. This research assessed all-cause and breast cancer-specific mortality of PET vs... Read More about Survival Outcomes in Older Women with Oestrogen-Receptor-Positive Early-Stage Breast Cancer: Primary Endocrine Therapy vs. Surgery by Comorbidity and Frailty Levels.

Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network (2023)
Journal Article
Aristei, C., Tomatis, M., Ponti, A., Marotti, L., Cardoso, M. J., Cheung, K. L., …Rubio, I. T. (2024). Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network. European Journal of Cancer, 196, Article 113438. https://doi.org/10.1016/j.ejca.2023.113438

Introduction
The present study was designed to describe tumour features and treatments for patients with breast cancer. It also aimed at assessing the risk of distant metastases in relation to biological profiles, disease stages and treatment.
Meth... Read More about Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network.

Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative (2023)
Journal Article
Galvin, A., Soubeyran, P., Brain, E., Cheung, K. L., Hamaker, M. E., Kanesvaran, R., …Bellera, C. (2023). Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative. Journal of Geriatric Oncology, Article 101611. https://doi.org/10.1016/j.jgo.2023.101611

As older adults with cancer are underrepresented in randomized clinical trials (RCT), there is limited evidence on which to rely for treatment decisions for this population. Commonly used RCT endpoints for the assessment of treatment efficacy are mor... Read More about Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative.

Geriatric assessment for older people with cancer: policy recommendations (2023)
Journal Article
Seghers, P. A., Alibhai, S. M., Battisti, N. M. L., Kanesvaran, R., Extermann, M., O’Donovan, A., …O’Hanlon, S. (2023). Geriatric assessment for older people with cancer: policy recommendations. Global Health Research and Policy, 8(1), Article 37. https://doi.org/10.1186/s41256-023-00323-0

Most cancers occur in older people and the burden in this age group is increasing. Over the past two decades the evidence on how best to treat this population has increased rapidly. However, implementation of new best practices has been slow and need... Read More about Geriatric assessment for older people with cancer: policy recommendations.

Oncoplastic breast surgery in older women with primary breast cancer: a systematic review (2023)
Journal Article
Chia, Z., Lee, R. X. N., Cardoso, M. J., Cheung, K. L., & Parks, R. M. (2023). Oncoplastic breast surgery in older women with primary breast cancer: a systematic review. British Journal of Surgery, 110(10), 1309-1315. https://doi.org/10.1093/bjs/znad161

Oncoplastic procedures allow excision of larger breast tumours, or unfavourable tumour/breast ratio lesions while achieving a good cosmetic outcome. This increases the pool of patients eligible for breast conservation over mastectomy, reducing the ne... Read More about Oncoplastic breast surgery in older women with primary breast cancer: a systematic review.

Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival (2023)
Journal Article
Kalvala, J., Parks, R. M., Abdi, J., Green, A. R., & Cheung, K. L. (2023). Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival. Advances in Therapy, https://doi.org/10.1007/s12325-023-02504-2

Introduction
Breast cancer in older women tends to have more favourable biology, compared to younger women. Androgen receptor (AR) is significant for breast tumour carcinogenesis; however, the role of AR in older women has not been fully explored.... Read More about Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival.