Outputs (97)

Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion (2020)
Journal Article
Elsheikh, S., Kouzoukakis, I., Fielden, C., Li, W., Lashin, S. E., Khair, N., …Ilyas, M. (2022). Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion. Journal of Clinical Pathology, 75(1), 24-29. https://doi.org/10.1136/jclinpath-2020-206871

Aims Ran GTPase is involved in nucleocytoplasmic shuttling of proteins and is overexpressed in several cancers. The expression of Ran in malignant melanoma (MM) and its functional activity have not been described and were investigated in this study.... Read More about Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion.

Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray (2020)
Journal Article
Parks, R. M., Albanghali, M. A., Syed, B. M., Green, A. R., Ellis, I. O., & Cheung, K. L. (2021). Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray. Breast Cancer Research and Treatment, 185(3), 647-655. https://doi.org/10.1007/s10549-020-06023-4

© 2020, The Author(s). Purpose: Prediction of response to primary endocrine therapy (PET) in older women is based on measurement of oestrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor (HER)-2. This study uses a uniq... Read More about Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray.

A same‐day assay predicts apoptotic response to combined BCL‐2 and MCL‐1 BH3‐mimetic targeting in multiple myeloma cells (2020)
Journal Article
Grundy, M., Al‐Kaisi, F., Cull, J., Williams, C., Smith, D., & Seedhouse, C. H. (2021). A same‐day assay predicts apoptotic response to combined BCL‐2 and MCL‐1 BH3‐mimetic targeting in multiple myeloma cells. eJHaem, 2(1), 40-47. https://doi.org/10.1002/jha2.133

Recent advances in treatment options for multiple myeloma (MM) have positive impact on patient survival. However, there is a short fall of rapid and reliable assays that can predict patient response to novel agents. The anti-apoptotic proteins B-cell... Read More about A same‐day assay predicts apoptotic response to combined BCL‐2 and MCL‐1 BH3‐mimetic targeting in multiple myeloma cells.

3D hydrogels reveal medulloblastoma subgroup differences and identify extracellular matrix subtypes that predict patient outcome (2020)
Journal Article
Linke, F., Aldighieri, M., Lourdusamy, A., Grabowska, A. M., Stolnik, S., Kerr, I. D., …Coyle, B. (2021). 3D hydrogels reveal medulloblastoma subgroup differences and identify extracellular matrix subtypes that predict patient outcome. Journal of Pathology, 253(3), 326-338. https://doi.org/10.1002/path.5591

© 2020 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. Medulloblastoma (MB) is the most common malignant brain tumour in children and is subdivided into... Read More about 3D hydrogels reveal medulloblastoma subgroup differences and identify extracellular matrix subtypes that predict patient outcome.

Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial (2020)
Journal Article
Korfage, I. J., Carreras, G., Arnfeldt Christensen, C. M., Billekens, P., Bramley, L., Briggs, L., …Rietjens, J. A. C. (2020). Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial. PLoS Medicine, 17(11), Article e1003422. https://doi.org/10.1371/journal.pmed.1003422

Background: Advance care planning (ACP) supportsindividuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomized clinical trials of ACP in patients with adva... Read More about Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial.

AKT isoforms have discrete expression in Triple Negative breast cancers and roles in cisplatin sensitivity (2020)
Journal Article
Khan, S., Wadhwa, B., Paddar, M., Malik, F., Mir, S., Clarke, P. A., …Malik, F. (2020). AKT isoforms have discrete expression in Triple Negative breast cancers and roles in cisplatin sensitivity. Oncotarget, 11, 4178-4194. https://doi.org/10.18632/oncotarget.27746

AKT, a serine threonine kinase, exists in three different isoforms and is known for regulating several biological processes including tumorigenesis. In this study, we investigated the expression and net effect of the individual isoforms in triple neg... Read More about AKT isoforms have discrete expression in Triple Negative breast cancers and roles in cisplatin sensitivity.

Nucleolar protein 10 (NOP10) predicts poor prognosis in invasive breast cancer (2020)
Journal Article
Elsharawy, K. A., Althobiti, M., Mohammed, O. J., Aljohani, A. I., Toss, M. S., Green, A. R., & Rakha, E. (2021). Nucleolar protein 10 (NOP10) predicts poor prognosis in invasive breast cancer. Breast Cancer Research and Treatment, 185(3), 615-627. https://doi.org/10.1007/s10549-020-05999-3

Purpose
Nucleolar protein 10 (NOP10) is required for ribosome biogenesis and telomere maintenance and plays a key role in carcinogenesis. This study aims to evaluate the clinical and prognostic significance of NOP10 in breast cancer (BC).

Methods... Read More about Nucleolar protein 10 (NOP10) predicts poor prognosis in invasive breast cancer.

Annual mammographic screening to reduce breast cancer mortality in women from age 40 years: long-term follow-up of the uk age rct (2020)
Journal Article
Duffy, S., Vulkan, D., Cuckle, H., Parmar, D., Sheikh, S., Smith, R., …Moss, S. (2020). Annual mammographic screening to reduce breast cancer mortality in women from age 40 years: long-term follow-up of the uk age rct. Health Technology Assessment, 24(55), 1-24. https://doi.org/10.3310/hta24550

Background There remains disagreement on the long-term effect of mammographic screening in women aged 40-49 years. Objectives The long-term follow-up of a randomised controlled trial that offered annual mammography to women aged 40-49 years. The esti... Read More about Annual mammographic screening to reduce breast cancer mortality in women from age 40 years: long-term follow-up of the uk age rct.

Markers of steroid receptor, kinase signalling pathways and Ki-67 expression in relation to tamoxifen sensitivity and resistance (2020)
Journal Article
Campbell, C., Mathew, J., Ellis, I. O., Bradbury, I., Borgquist, S., Elebro, K., …Robertson, J. F. R. (2020). Markers of steroid receptor, kinase signalling pathways and Ki-67 expression in relation to tamoxifen sensitivity and resistance. Translational Breast Cancer Research, 1, Article 29. https://doi.org/10.21037/tbcr-20-31

Background: It remains clinically important to identify ER positive breast cancers likely to respond to tamoxifen (TAM) and so we aimed to select a group of biomarkers able to predict response. We also assessed whether data from different sample type... Read More about Markers of steroid receptor, kinase signalling pathways and Ki-67 expression in relation to tamoxifen sensitivity and resistance.

Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells (2020)
Journal Article
Pérez-Cota, F., Fuentes-Domínguez, R., La Cavera III, S., Hardiman, W., Yao, M., Setchfield, K., …Clark, M. (2020). Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells. Journal of Applied Physics, 128(16), Article 160902. https://doi.org/10.1063/5.0023744

© 2020 Author(s). Characterization of the elasticity of biological cells is growing as a new way to gain insight into cell biology. Cell mechanics are related to most aspects of cellular behavior, and applications in research and medicine are broad.... Read More about Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells.