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Outputs (78)

A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxymethylcytosine levels (2014)
Journal Article
Ciccone, N. A., Ruzov, A., Mwangi, W., Smith, L. P., Butter, C., & Nair, V. (2014). A B-cell targeting virus disrupts potentially protective genomic methylation patterns in lymphoid tissue by increasing global 5-hydroxymethylcytosine levels. Veterinary Research, 45, Article 108. https://doi.org/10.1186/s13567-014-0108-5

Novel cell lines isolated from mouse embryonic stem cells exhibiting de novo methylation of the E-cadherin promoter. (2014)
Journal Article
Hawkins, K., Keramari, M., Soncin, F., Segal, J. M., Mohamet, L., Miazga, N., Ritson, S., Bobola, N., Merry, C. L. R., & Ward, C. M. (2014). Novel cell lines isolated from mouse embryonic stem cells exhibiting de novo methylation of the E-cadherin promoter. STEM CELLS, 32(11), 2869-2879. https://doi.org/10.1002/stem.1790

Mouse embryonic stem cells (mESCs) and epiblast stem cells represent the naïve and primed pluripotent states, respectively. These cells self‐renew via distinct signaling pathways and can transition between the two states in the presence of appropriat... Read More about Novel cell lines isolated from mouse embryonic stem cells exhibiting de novo methylation of the E-cadherin promoter..

Impact of pre-transplant co-morbidities on outcome after alemtuzumab-based reduced intensity conditioning allo-SCT in elderly patients: A British Society of Blood and Marrow Transplantation study (2014)
Journal Article
Nikolousis, E., Nagra, S., Pearce, R., Perry, J., Kirkland, K., Byrne, J., Dignan, F., Tholouli, E., Gilleece, M., Russell, N., Littlewood, T., Cook, M., Peniket, A., Shaw, B. E., Cook, G., & Craddock, C. (2014). Impact of pre-transplant co-morbidities on outcome after alemtuzumab-based reduced intensity conditioning allo-SCT in elderly patients: A British Society of Blood and Marrow Transplantation study. Bone Marrow Transplantation, 50, 82-86. https://doi.org/10.1038/bmt.2014.215

The advent of reduced intensity conditioning (RIC) regimens has permitted the extension of allo-SCT to selected patients into their eighth decade but GVHD remains a major cause of morbidity and mortality. Alemtuzumab is increasingly used to reduce th... Read More about Impact of pre-transplant co-morbidities on outcome after alemtuzumab-based reduced intensity conditioning allo-SCT in elderly patients: A British Society of Blood and Marrow Transplantation study.

The clinicopathological and gene expression patterns associated with ulceration of primary melanoma (2014)
Journal Article
Jewell, R., Elliott, F., Laye, J., Nsengimana, J., Davies, J., Walker, C., Conway, C., Mitra, A., Harland, M., Cook, M. G., Boon, A., STORR, S., Safuan, S., MARTIN, S., Jirström, K., Olsson, H., Ingvar, C., Lauss, M., Bishop, T., Jönsson, G., & Newton‐Bishop, J. (2015). The clinicopathological and gene expression patterns associated with ulceration of primary melanoma. Pigment Cell and Melanoma Research, 28(1), 94-104. https://doi.org/10.1111/pcmr.12315

Use of humanised rat basophilic leukaemia cell line RSATL8 for the assessment of allergenicity of Schistosoma mansoni proteins (2014)
Journal Article
Alcocer, M., Wan, D., Ludolf, F., Alanine, D. G. W., Stretton, O., Ali Ali, E., Al-Barwary, N., Wang, X., Doenhoff, M. J., Mari, A., Fitzsimmons, C. M., Dunne, D. W., Nakamura, R., Oliveira, G. C., & Falcone, F. H. (2014). Use of humanised rat basophilic leukaemia cell line RSATL8 for the assessment of allergenicity of Schistosoma mansoni proteins. PLoS Neglected Tropical Diseases, 8(9), 1-13. https://doi.org/10.1371/journal.pntd.0003124

Background

Parasite-specific IgE is thought to correlate with protection against Schistosoma mansoni infection or re-infection. Only a few molecular targets of the IgE response in S. mansoni infection have been characterised. A better insight into... Read More about Use of humanised rat basophilic leukaemia cell line RSATL8 for the assessment of allergenicity of Schistosoma mansoni proteins.

Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells (2014)
Journal Article
Filipović, A., Lombardo, Y., Fronato, M., Abrahams, J., Aboagye, E., Nguyen, Q.-D., d’Aqua, B. B., Ridley, A., Green, A., Rahka, E., Ellis, I., Recchi, C., Przulj, N., Sarajlić, A., Alattia, J.-R., Fraering, P., Deonarain, M., & Coombes, R. C. (2014). Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells. Breast Cancer Research and Treatment, 148(2), 455-462. https://doi.org/10.1007/s10549-014-3119-z

The goal of targeted cancer therapies is to specifically block oncogenic signalling, thus maximising efficacy, while reducing side-effects to patients. The gamma-secretase (GS) complex is an attractive therapeutic target in haematological malignancie... Read More about Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells.

Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers? (2014)
Journal Article
Abdel-Fatah, T. M., Perry, C., Arora, A., Thompson, N., Doherty, R., Moseley, P. M., Green, A. R., Chan, S. Y., Ellis, I. O., & Madhusudan, S. (2014). Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?. Antioxidants and Redox Signaling, 21(16), 2262-2268. https://doi.org/10.1089/ars.2014.6077

Estrogen and estrogen metabolite-induced reactive oxygen species generation can promote oxidative DNA base damage. If unrepaired, base damaging lesions could accelerate mutagenesis, leading to a “mutator phenotype” characterized by aggressive behavio... Read More about Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?.

The TRAIL system is over-expressed in breast cancer and FLIP a marker of good prognosis (2014)
Journal Article
Ullenhag, G. J., Al-Attar, A., Mukherjee, A., Green, A. R., Ellis, I. O., & Durrant, L. G. (2015). The TRAIL system is over-expressed in breast cancer and FLIP a marker of good prognosis. Journal of Cancer Research and Clinical Oncology, 141(3), 505-514. https://doi.org/10.1007/s00432-014-1822-0

Background

Breast cancer is the most common cancer in women. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway transmits apoptotic signals. Novel anticancer agents that activate this system are in clinical development, in... Read More about The TRAIL system is over-expressed in breast cancer and FLIP a marker of good prognosis.