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High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer (2020)
Conference Proceeding
Heyman, T., Joseph, C., Craze, M., Green, A., Nolan, C., Rueda, O., …Mukherjee, A. (2020). High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer

Background & objectives TIMP2, tissue inhibitor of matrix-metalloproteinase 2, inhibits the matrix-metalloproteinase, MMP2, but may activate pro-MMP2. Hence its correlation with prognosis in breast cancer (BC) is contradictory. This study investigat... Read More about High tissue inhibitor of matrix-metalloproteinase 2 expression correlates with poor prognosis in breast cancer.

Quantifying the core deficit in classical schizophrenia (2020)
Journal Article
Rathnaiah, M., Liddle, E., Gascoyne, L., Kumar, J., Zia Ul Haq Katshu, M., Faruqi, C., …Liddle, P. F. (2020). Quantifying the core deficit in classical schizophrenia. Schizophrenia Bulletin Open, 1(1), Article sgaa031. https://doi.org/10.1093/schizbullopen/sgaa031

In the classical descriptions of schizophrenia, Kraepelin and Bleuler recognised disorganization and impoverishment of mental activity as fundamental symptoms. Their classical descriptions also included a tendency to persisting disability. The psycho... Read More about Quantifying the core deficit in classical schizophrenia.

Coordinate based meta-analysis of networks in neuroimaging studies (2019)
Journal Article
Tench, C., Tanasescu, R., Constantinescu, C., Cottam, W., & Auer, D. (2020). Coordinate based meta-analysis of networks in neuroimaging studies. NeuroImage, 205, 1-12. https://doi.org/10.1016/j.neuroimage.2019.116259

Meta-analysis of summary results from published neuroimaging studies independently testing a common hypothesis is performed using coordinate based meta-analysis (CBMA), which tests for consistent activation (in the case of functional MRI studies) of... Read More about Coordinate based meta-analysis of networks in neuroimaging studies.

Differential effects of resveratrol on the dilator responses of femoral arteries, ex vivo (2019)
Journal Article
Diaz, M., Parikh, V., Ismail, S., Maxamed, R., Tye, E., Austin, C., …Azzawi, M. (2019). Differential effects of resveratrol on the dilator responses of femoral arteries, ex vivo. Nitric Oxide: Biology and Chemistry, 92, 1-10. https://doi.org/10.1016/j.niox.2019.07.008

Resveratrol is a plant-derived phytoalexin with antioxidant, anti-inflammatory and cardio-protective properties and may be a promising therapeutic intervention strategy in cardiovascular disease. Here, we investigated the acute direct effects of tran... Read More about Differential effects of resveratrol on the dilator responses of femoral arteries, ex vivo.

Oral green tea catechins do not provide photoprotection from direct DNA damage induced by higher dose solar simulated radiation: A randomized controlled trial (2018)
Journal Article
Farrar, M. D., Huq, R., Mason, S., Nicolaou, A., Clarke, K. A., Dew, T. P., …Rhodes, L. E. (2018). Oral green tea catechins do not provide photoprotection from direct DNA damage induced by higher dose solar simulated radiation: A randomized controlled trial. Journal of The American Academy of Dermatology, 78(2), 414-416. https://doi.org/10.1016/j.jaad.2017.08.021

Green tea catechins and their metabolites in human skin before and after exposure to ultraviolet radiation (2015)
Journal Article
Clarke, K. A., Dew, T. P., Watson, R. E., Farrar, M. D., Osman, J. E., Nicolaou, A., …Williamson, G. (2016). Green tea catechins and their metabolites in human skin before and after exposure to ultraviolet radiation. Journal of Nutritional Biochemistry, 27, 203-210. https://doi.org/10.1016/j.jnutbio.2015.09.001

Dietary flavonoids may protect against sunburn inflammation in skin. Preliminary reports using less complete analysis suggest that certain catechins and their metabolites are found in skin biopsies and blister fluid after consumption of green tea; ho... Read More about Green tea catechins and their metabolites in human skin before and after exposure to ultraviolet radiation.

A randomized controlled trial of green tea catechins in protection against ultraviolet radiation–induced cutaneous inflammation (2015)
Journal Article
Farrar, M. D., Nicolaou, A., Clarke, K. A., Mason, S., Massey, K. A., Dew, T. P., …Rhodes, L. E. (2015). A randomized controlled trial of green tea catechins in protection against ultraviolet radiation–induced cutaneous inflammation. American Journal of Clinical Nutrition, 102(3), 608-615. https://doi.org/10.3945/ajcn.115.107995

Background: Safe systemic protection from the health hazards of ultraviolet radiation (UVR) in sunlight is desirable. Green tea is consumed globally and is reported to have anti-inflammatory properties, which may be mediated through the impact on cyc... Read More about A randomized controlled trial of green tea catechins in protection against ultraviolet radiation–induced cutaneous inflammation.

Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans (2015)
Journal Article
Actis-Goretta, L., Dew, T. P., Lévèques, A., Pereira-Caro, G., Rein, M., Teml, A., …Williamson, G. (2015). Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans. Molecular Nutrition and Food Research, 59(9), 1651-1662. https://doi.org/10.1002/mnfr.201500202

Scope Hesperetin?7?O ?rutinoside (hesperidin) reduces blood pressure in healthy volunteers but its intestinal absorption and metabolism are not fully understood. Therefore, we aimed to determine sites of absorption and metabolism of dietary flavanon... Read More about Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans.

High performance liquid chromatography tandem mass spectrometry dual extraction method for identification of green tea catechin metabolites excreted in human urine (2014)
Journal Article
Clarke, K. A., Dew, T. P., Watson, R. E., Farrar, M. D., Bennett, S., Nicolaou, A., …Williamson, G. (2014). High performance liquid chromatography tandem mass spectrometry dual extraction method for identification of green tea catechin metabolites excreted in human urine. Journal of Chromatography B, 972, 29-37. https://doi.org/10.1016/j.jchromb.2014.09.035

The simultaneous analysis of free-form and conjugated flavonoids in the same sample is difficult but necessary to properly estimate their bioavailability. A method was developed to optimise the extraction of both free and conjugated forms of catechin... Read More about High performance liquid chromatography tandem mass spectrometry dual extraction method for identification of green tea catechin metabolites excreted in human urine.

Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation (2014)
Journal Article
Wightman, E. L., Reay, J. L., Haskell, C. F., Williamson, G., Dew, T. P., & Kennedy, D. O. (2014). Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. British Journal of Nutrition, 112(2), 203-213. https://doi.org/10.1017/s0007114514000737

Previous research has shown that resveratrol can increase cerebral blood flow (CBF) in the absence of improved cognitive performance in healthy, young human subjects during the performance of cognitively demanding tasks. This lack of cognitive effect... Read More about Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation.