@article { , title = {Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson’s disease}, abstract = {Objectives Firstly, to identify subthalamic region stimulation clusters that predict maximum improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and secondly, to map-out the cortical fingerprint, mediated by the hyperdirect pathways which predict maximum efficacy. Methods High angular resolution diffusion imaging in twenty patients with advanced Parkinson’s disease was acquired prior to bilateral subthalamic nucleus deep brain stimulation. All contacts were screened one-year from surgery for efficacy and side-effects at different amplitudes. Voxel-based statistical analysis of volumes of tissue activated models was used to identify significant treatment clusters. Probabilistic tractography was employed to identify cortical connectivity patterns associated with treatment efficacy. Results All patients responded well to treatment (46\% mean improvement off medication UPDRS-III [p}, doi = {10.1016/j.neuroimage.2017.07.012}, eissn = {1095-9572}, issn = {1053-8119}, journal = {NeuroImage}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://nottingham-repository.worktribe.com/output/966437}, volume = {158}, keyword = {Sir Peter Mansfield Imaging Centre (SPMIC), Beacon - Precision Imaging, Diffusion weighted imaging (DWI), connectivity, Parkinson’s disease (PD), subthalamic nucleus (STN), volume of tissue activated (VTA), hyperdirect pathway}, year = {2017}, author = {Akram, Harith and Sotiropoulos, Stamatios N. and Jbabdi, Saad and Georgiev, Dejan and Mahlknecht, Philipp and Hyam, Jonathan and Foltynie, Thomas and Limousin, Patricia and De Vita, Enrico and Jahanshahi, Marjan and Hariz, Marwan and Ashburner, John and Behrens, Timothy and Zrinzo, Ludvic} }