@article { , title = {Hidden dangers of antibiotic use: increased gut permeability mediated by increased pancreatic proteases reaching the colon}, abstract = {As we learn more about the importance of our microbiome in inflammatory, metabolic, and functional disorders, we are coming to appreciate the risks of disturbing this with broad-spectrum antibiotics. We have known for many years that as antibiotics have dramatically reduced the risk of infectious diseases, the incidence of other diseases such as inflammatory bowel disease, obesity, and type 2 diabetes mellitus have increased. Although the causes undoubtedly are multifactorial, meta-analysis showed that for Crohn’s disease (CD), antibiotic exposure nearly doubles the risk.}, doi = {10.1016/j.jcmgh.2018.06.005}, eissn = {2352-345X}, issue = {3}, journal = {Cellular and Molecular Gastroenterology and Hepatology}, note = {Open Access (CC BY NC ND) article. OL 17.07.2018. Updated OL 07.08.2018}, pages = {347–348.e1}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://nottingham-repository.worktribe.com/output/946684}, volume = {6}, year = {2018}, author = {Spiller, Robin C.} }