@article { , title = {Beyond obesity - thermogenic adipocytes and cardiometabolic health}, abstract = {The global prevalence of obesity and related cardiometabolic disease continues to increase through the 21st century. Whilst multi-factorial, obesity is ultimately caused by chronic caloric excess. However, despite numerous interventions focussing on reducing caloric intake these either fail or only elicit short-term changes in body mass. There is now a focus on increasing energy expenditure instead which has stemmed from the recent ‘re-discovery’ of cold-activated brown adipose tissue (BAT) in adult humans and inducible ‘beige’ adipocytes. Through the unique mitochondrial uncoupling protein (UCP1), these thermogenic adipocytes are capable of combusting large amounts of chemical energy as heat and in animal models can prevent obesity and cardiometabolic disease. At present, human data does not point to a role for thermogenic adipocytes in regulating body weight or fat mass but points to a pivotal role in regulating metabolic health by improving insulin resistance as well as glucose and lipid homeostasis. This review will therefore focus on the metabolic benefits of BAT activation and the mechanisms and signalling pathways by which these could occur including improvements in insulin signalling in peripheral tissues, systemic lipid and cholesterol metabolism and cardiac and vascular function.}, doi = {10.1515/hmbci-2017-0007}, eissn = {1868-1891}, issn = {1868-1883}, issue = {2}, journal = {Hormone Molecular Biology and Clinical Investigation}, note = {Will be CC BY if OA form accepted. Replace AAM with publisher's PDF, change to available to all (green OA is 12 m. embargo) Amend RIOXX and CC BY screens. Add doi + vol. details. Michael Symonds emailed for publication notification. KJH 31.03.17. Have added final published version sent by author as the online articles have to be purchased. Article has not yet been published online so unable to check if it has been made open access. Have asked author to confirm. Retain both PDFs until article published online. KJB 02.06.2017 Published online 26.05.2017. Not OA. KJH 14.08.17}, publicationstatus = {Published}, publisher = {De Gruyter}, url = {https://nottingham-repository.worktribe.com/output/861867}, volume = {31}, keyword = {brown adipose tissue, cardiometabolic health, glucose metabolism, insulin signalling, lipid metabolism}, author = {Aldiss, Peter and Dellschaft, Neele S. and Sacks, Harold and Budge, Helen and Symonds, Michael E.} }