@article { , title = {Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology}, abstract = {A miniaturized, high-throughput assay was optimized to screen polymer-drug solid dispersions using a 2-D Ink-jet printer. By simply printing nanoliter amounts of polymer and drug solutions onto an inert surface, drug:polymer micro-dots of tunable composition were produced in an easily-addressable micro-array format. The amount of material printed for each dried spot ranged from 25 ng to 650 ng. These arrays were used to assess the stability of drug:polymer dispersions with respect to recrystallization, using polarized light microscopy. One array with a panel of 6 drugs formulated at different ratios with Poly (vinylpyrrolidone-vinyl acetate) copolymer (PVPVA) was developed to estimate a possible bulk (gram-scale) approximation threshold from the final printed nano amount of formulation. Another array was printed at a fixed final amount of material to establish a literature comparison of one drug formulated with different commercial polymers for validation. This new approach may offer significant efficiency in pharmaceutical formulation screening, with each experiment in the nano-micro-array format requiring from 3 up to 6 orders of magnitude lower amounts of sample than conventional screening methods.}, doi = {10.1021/acs.molpharmaceut.7b00182}, eissn = {1543-8384}, issn = {1543-8384}, issue = {6}, journal = {Molecular Pharmaceutics}, publicationstatus = {Published}, publisher = {American Chemical Society}, url = {https://nottingham-repository.worktribe.com/output/860398}, volume = {14}, keyword = {High throughput array, Ink-jet printing, Amorphous dispersion, Recrystallisation, Polarizing microscopy}, author = {Taresco, Vincenzo and Louzao, Iria and Scurr, David J. and Turpin, Eleanor R. and Laughton, Charles A. and Alexander, Cameron and Burley, Jonathan C. and Garnett, Martin} }