@article { , title = {Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time}, abstract = {Ovine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and eluted prion was used to challenge tg338 mice transgenic for ovine PrP. After one-day incubation on soil, two PrPSc phenotypes were present: G338 or Apl338ii. Thirteen months later some divergent PrPSc phenotypes were seen: a mixture of Apl338ii with either G338 or P338, and a completely novel PrPSc deposition, designated Cag338. The data show that prolonged ageing of scrapie prions within an environmental matrix may result in changes in the dominant PrPSc biological/biochemical properties.}, doi = {10.1186/s13567-015-0179-y}, eissn = {0928-4249}, issn = {0928-4249}, journal = {Veterinary Research}, publicationstatus = {Published}, publisher = {Springer Verlag}, url = {https://nottingham-repository.worktribe.com/output/748547}, volume = {46}, year = {2015}, author = {Maddison, Ben C. and Spiropoulos, John and Vickery, Christopher M. and Lockey, Ricahrd and Owen, Jonathan P. and Bishop, Keith and Baker, Claire A. and Gough, Kevin C.} }