@article { , title = {A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men}, abstract = {AbstractInclusion in nasogastric tube feeds (NGTF) of acid-sensitive, seaweed-derived alginate, expected to form a reversible gel in the stomach, may create a more normal intragastric state and modified gastrointestinal responses. This may ameliorate NGTF-associated risk of diarrhoea, upper gastrointestinal symptoms and appetite suppression. In a randomised, crossover, comparison study, undertaken in twelve healthy males, an alginate-containing feed (F + ALG) or one that was alginate-free (F-ALG) (300 ml) was given over 1 h with a 7–14-d washout period between treatments. Baseline and for 4-h post-feed initiation, MRI measurements were made to establish small bowel water content (SBWC), gastric contents volume (GCV) and appearance, and superior mesenteric artery blood flux. Blood glucose and gut peptides were measured. Subjective appetite and upper gastrointestinal symptoms scores were obtained. Ad libitum pasta consumption 3-h post-feeding was measured. F + ALG exhibited a gastric appearance consistent with gelling surrounded by a freely mobile water halo. Significant main effects of feed were seen for SBWC (P = 0·03) and peptide YY (PYY) (P = 0·004) which were attributed to generally higher values for SBWC with F + ALG (max difference between adjusted means 72 ml at 210 min) and generally lower values for PYY with F + ALG. GCV showed a faster reduction with F + ALG, less between-participant variation and a feed-by-time interaction (P = 0·04). Feed-by-time interactions were also seen with glucagon-like-peptide 1 (GLP-1) (P = 0·02) and glucose-dependent insulinotropic polypeptide (GIP) (P = 0·002), both showing a blunted response with F + ALG. Apparent intragastric gelling with F + ALG and subsequent differences in gastrointestinal and endocrine responses have been demonstrated between an alginate-containing and alginate-free feed.}, doi = {10.1017/S0007114523000302}, eissn = {1475-2662}, issn = {0007-1145}, issue = {8}, journal = {British Journal of Nutrition}, note = {Article not yet published online. On temp embargo sheet. Will need to change status to published. Will need to add official url, volume, issue, pagination and doi. Will need to set 6 month embargo on publication. KJB 3.2.23}, pages = {1316-1328}, publicationstatus = {Published}, publisher = {Cambridge University Press (CUP)}, url = {https://nottingham-repository.worktribe.com/output/16800374}, volume = {130}, keyword = {Nutrition and Dietetics, Medicine (miscellaneous)}, year = {2023}, author = {Aliyu, Abdulsalam I. and Nixon, Aline and Hoad, Caroline and Marciani, Luca and Corsetti, Maura and Aithal, Guruprasad P. and Macdonald, Ian A. and Cordon, Sally M. and Alhussain, Maha H. and Inoue, Hiroaki and Yamada, Masahiko and Taylor, Moira A.} }