@article { , title = {Evolution of treatment targets in Crohn’s disease}, abstract = {Crohn’s disease is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract, associated with significantly morbidity due to both symptoms and complications that have a considerable detrimental impact on a patient’s quality of life. An early treat to target approach with disease modifying agents has been shown to significantly improve long term outcomes, demonstrated by a number of therapeutic targets in a number of modalities. This review will outline the current treatment targets and measures of disease burden in Crohn’s disease.}, doi = {10.1016/j.bpg.2019.02.001}, eissn = {1532-1916}, issn = {1521-6918}, journal = {Best Practice \& Research Clinical Gastroenterology}, pages = {1-9}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://nottingham-repository.worktribe.com/output/1572006}, volume = {38-39}, keyword = {Crohn’s disease, Treatment targets, Patient reported outcomes, Clinician reported activity indices, Biomarkers, Endoscopy, Imaging, Histology}, year = {2019}, author = {White, Jonathan R. and Jairath, Vipul and Moran, Gordon W.} }