@article { , title = {Synthesis of Arylidenehydrazinyl‐4‐methoxyphenylthiazole Derivatives: Docking Studies, Probing Type II Diabetes Complication Management Agents}, abstract = {Thiazole has been a key scaffold in antidiabetic drugs. In quest of new and more effective drugs a simple, efficient, high yielding (67–79 \%) and convenient synthesis of arylidenehydrazinyl-4-methoxyphenyl)thiazoles is accomplished over two steps. The synthesis involved the condensation of aryl substituted thiosemicarbazones and 2-bromo-4-methoxyacetophenone in absolute ethanol. The structures of the resulting thiazoles are in accord with their UV/VIS, FT-IR, 1H-, 13C-NMR and HRMS data. All compounds were evaluated for alpha(α)-amylase inhibition potential, antiglycation, antioxidant abilities and biocompatibility. The compounds library identified 2-(2-(3,4-dichlorobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole as a lead molecule against α-amylase inhibition with an IC50 of 5.75±0.02 μM. α-Amylase inhibition is also supported by molecular docking studies against α-amylase. All the obtained thiazoles also showed promising antiglycation activity with 4-(4-methoxyphenyl)-2-\{2-[2-(trifluoromethyl)benzylidene]hydrazinyl\}thiazole exhibiting the best inhibition (IC50= 0.383±0.001 mg/mL) compared to control. The tested compounds are also biocompatible at the concentration used i. e., 10 μM.}, doi = {10.1002/cbdv.202200824}, eissn = {1612-1880}, issn = {1612-1872}, issue = {11}, journal = {Chemistry and Biodiversity}, publicationstatus = {Published}, url = {https://nottingham-repository.worktribe.com/output/12597528}, volume = {19}, keyword = {Molecular Biology, Molecular Medicine, General Chemistry, Biochemistry, General Medicine, Bioengineering}, year = {2022}, author = {Mehmood, Hasnain and Akhtar, Tashfeen and Haroon, Muhammad and Tahir, Ehsaan and Ehsan, Muhammad and Woodward, Simon and Musa, Mustapha} }