@article { , title = {The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation}, abstract = {Objective To evaluate the impact of the Quintet Recruitment Intervention (QRI) on recruitment in challenging randomized controlled trials (RCTs) that have applied the intervention. The QRI aims to understand recruitment difficulties, and then implements ‘QRI-actions’ to address these as recruitment proceeds. Study Design and Setting A mixed-methods study, comprising: a) before-and-after comparisons of recruitment rates and numbers of patients approached, and b) qualitative case studies, including documentary analysis and interviews with RCT investigators. Results Five UK-based publicly-funded RCTs were included in the evaluation. All recruited to target. RCT2 and RCT5 both received up-front pre-recruitment training before the intervention was applied. RCT2 did not encounter recruitment issues and recruited above target from its outset. Recruitment difficulties, particularly communication issues, were identified and addressed through QRI-actions in RCTs 1, 3, 4 and 5. Randomization rates significantly improved post-QRI-action in RCTs 1,3, and 4. QRI-actions addressed issues with approaching eligible patients in RCTs 3 and 5, which both saw significant increases in patients approached. Trial investigators reported that the QRI had unearthed issues they had been unaware of, and reportedly changed their practices post QRI-action. Conclusion There is promising evidence to suggest the QRI can support recruitment to difficult RCTs. This needs to be substantiated with future controlled evaluations.}, doi = {10.1016/j.jclinepi.2018.10.004}, eissn = {1878-5921}, issn = {0895-4356}, journal = {Journal of Clinical Epidemiology}, pages = {108-120}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://nottingham-repository.worktribe.com/output/1233541}, volume = {106}, keyword = {Randomized Controlled Trial, Clinical trial, Recruitment, Training healthcare professionals, Qualitative research, Communication}, year = {2019}, author = {L, Rooshenas and LJ, Scott and JM, Blazeby and CA, Rogers and KM, Tilling and S, Husbands and C, Conefrey and N, Mills and RC, Stein and C, Metcalfe and AJ, Carr and DJ, Beard and T., Davis and S, Paramasivan and M, Jepson and K, Avery and D, Elliott and C, Wilson and JL, Donovan and Rogers, Chris A. and Andrews, Robert and Blazeby, Jane M. and Byrne, James and Donovan, Jenny L. and Kelly, Jamie and Mazza, Graziella and Mahon, David and Noble, Hamish and Reeves, Barnaby C. and Thompson, Janice L. and Wordsworth, Sarah and Welbourn, Richard and Beard, David and Carr, Andrew and Cook, Jonathan and Cooper, Cushla and Dean, Benjamin and Donovan, Jenny L. and Gray, Alastair and Gwilym, Stephen and Judge, Andrew and Merritt, Naomi and Moser, Jane and Rees, Jonathan and Rombach, Ines and Savulescu, Julian and Tracey, Irene and Wartolowska, Karolina and Tan, Wei and Mills, Nicola and Karantana, Alexia and Sprange, Kirsty and Duley, Lelia and Elliott, Daisy and Blazeby, Jane M. and Hollingworth, William and Montgomery, Alan A. and Davis, Tim and Stein, Rob and Bartlett, John and Cameron, David and Campbell, Amy and Canney, Peter and Donovan, Jenny L. and Dunn, Janet and Earl, Helena and Falzon, Mary and Francis, Adele and Hall, Peter and Harmer, Victoria and Higgins, Helen and Hiller, Louise and Hughes-Davies, Luke and Hulme, Claire and Macpherson, Iain and Makris, Andreas and Marshall, Andrea and McCabe, Christopher and Morgan, Adrienne and Pinder, Sarah and Poole, Christopher and Provenzano, Elena and Rea, Daniel and Stallard, Nigel and Avery, Kerry NL. and Barham, C Paul and Berrisford, Richard and Blazeby, Jane M. and Donovan, Jenny L. and Elliott, Jackie and Falk, Stephen J. and Goldin, Rob and Hanna, George and Hollowood, Andrew A. and Krysztopik, Richard and Metcalfe, Chris and Noble, Sian and Sanders, Grant and Streets, Christopher G. and Titcomb, Dan R. and Wheatley, Tim} }